Jane Fairfax from Emma by Jane Austen (This was the first one that jumped to my mind when I read this week's category - probably because I'm reading Emma right now. I have nothing against Jane Fairfax. I'm sure she's a lovely person. She's just not someone I can see being my best friend.)
Pretty much any character from The Casual Vacancy by J.K. Rowling (Sorry. I just couldn't force myself to care about any of them.)
Claudia from Pilate's Wife by Antoinette May
Jessie Sullivan from The Mermaid Chair by Sue Monk Kidd (Both Claudia and Jessie decide that the solution to their angst is to have an affair. I hate that sort of plot, and I have no respect for the characters that choose it!)
Courtney Stone from Confessions of a Jane Austen Addict by Laurie Viera Rigler (Too whiny.)
Auralia from Auralia's Colors by Jeffrey Overstreet (She didn't do anything. For pretty much the whole book.)
William Baker from The Last Enchantments by Charles Finch (I usually love the whole year-at-a-British-university sort of plot, but William was just too lost and too dependent on others to make me interested in what happened to him.)
Most - but not all - of the women from The Reading Group by Elizabeth Noble (It's normal to feel unhappy with your life sometimes. But again, these characters chose to solve that problem by making decisions I didn't respect. I just couldn't relate!)